5,6,7,8-Tetrahydro-2-naphthol

Names

[ Name ]:
5,6,7,8-Tetrahydro-2-naphthol

[Synonym ]:
MFCD00001738
2-Naphthalenol, 5,6,7,8-tetrahydro-
5,6,7,8-Tetrahydro-2-naphthalenol
5,6,7,8-tetrahydronaphthalen-2-ol
2-hydroxy-5,6,7,8-tetrahydronaphthalene
6-Hydroxytetraline
6-Tetralinol
6-Tetralinolagon
5,6,7,8-Tetrahydro-2-naphthol
6-Hydroxytetralin
TETRAHYDRO-2-NAPHTHOL
EINECS 214-410-4
5,6,7,8-tetrahydro-2-hydroxy naphthalene
5,6,7,8-tetrahydro-naphthalen-2-ol
6-hydroxy-1,2,3,4-tetrahydronaphthalene

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
275.5±0.0 °C at 760 mmHg

[ Melting Point ]:
59-61 °C(lit.)

[ Molecular Formula ]:
C₁₀H₁₂O

[ Molecular Weight ]:
148.202

[ Flash Point ]:
131.8±12.8 °C

[ Exact Mass ]:
148.088821

[ PSA ]:
20.23000

[ LogP ]:
3.17

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.582

[ Storage condition ]:
Room temperature.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QL5300000

CHEMICAL NAME :: 2-Naphthol, 5,6,7,8-tetrahydro-

CAS REGISTRY NUMBER :: 1125-78-6

LAST UPDATED :: 198910

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H12-O

MOLECULAR WEIGHT :: 148.22

WISWESSER LINE NOTATION :: L66&TJ BQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9600 mg/kg/30W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 19,413,1959

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4144 mg/kg/14W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 19,413,1959

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
QL5300000

[ HS Code ]:
29071900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2907199090

[ Summary ]:
2907199090 other monophenols VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

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Chemosphere 73(8) , 1216-23, (2008)

The photochemical transformation of natural estrogenic steroid 17beta-estradiol (E2) and the synthetic oral contraceptive 17alpha-ethinylestradiol (EE2) has been studied in dilute non buffered aqueous...

An electron spin resonance study of o-semiquinones formed during the enzymatic and autoxidation of catechol estrogens.

J. Biol. Chem. 259(22) , 14018-22, (1984)

Electron spin resonance spectroscopy has been used to demonstrate production of semiquinone-free radicals from the oxidation of the catechol estrogens 2- and 4-hydroxyestradiol and 2,6- and 4,6-dihydr...

Estrone sulfonates as inhibitors of estrone sulfatase.

Steroids 62(4) , 346-50, (1997)

In our continuing quest to design efficient inhibitors of estrone sulfatase activity and to assess the recognition of estrone sulfate surrogates by estrone sulfatase, we synthesized and evaluated seve...