3'-Demethylnobiletin

Names

[ Name ]:
3'-Demethylnobiletin

[Synonym ]:
4H-1-Benzopyran-4-one,2-(3-hydroxy-4-methoxyphenyl)-5,6,7,8-tetramethoxy
3'-hydroxy-5,6,7,8,4'-pentamethoxyflavone
7-Hydroxy-3',4',5,6-tetramethoxyflavone
3'-Demethylnobiletin

Biological Activity

[Description]:

3'-Demethylnobiletin, a derivative of Nobiletin, is a polymethoxyflavonoid in citrus fruits[1]. Nobiletin exhibits anticancer activity and inhibits tumor angiogenesis by regulating Src, FAK, and STAT3 signaling[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Murakami A, et al. In vitro absorption and metabolism of nobiletin, a chemopreventive polymethoxyflavonoid in citrus fruits. Biosci Biotechnol Biochem. 2001 Jan;65(1):194-7.

[2]. Sp N, et al. Nobiletin Inhibits Angiogenesis by Regulating Src/FAK/STAT3-Mediated Signaling through PXN in ER⁺ Breast Cancer Cells. Int J Mol Sci. 2017 Apr 30;18(5). pii: E935.

Chemical & Physical Properties

[ Density]:
1.304g/cm3

[ Boiling Point ]:
613.8ºC at 760 mmHg

[ Melting Point ]:
170-171 ºC

[ Molecular Formula ]:
C₂₀H₂₀O₈

[ Molecular Weight ]:
388.36800

[ Flash Point ]:
218.8ºC

[ Exact Mass ]:
388.11600

[ PSA ]:
96.59000

[ LogP ]:
3.20860

[ Vapour Pressure ]:
1.17E-15mmHg at 25°C

[ Index of Refraction ]:
1.582

[ Water Solubility ]:
Practically insoluble (0.039 g/L) (25 ºC)

3'-Demethylnobiletin

Names

Biological Activity

Chemical & Physical Properties

Related Compounds