7-[(1,4,5,6-Tetrahydro-4-methyl-6-oxopyridazin)-3-yl]-4H-1,4-benzoxazin-3(2H)-one

Names

[ CAS No. ]:
112018-01-6

[ Name ]:
7-[(1,4,5,6-Tetrahydro-4-methyl-6-oxopyridazin)-3-yl]-4H-1,4-benzoxazin-3(2H)-one

[Synonym ]:
6-[3,4-dihydro-3-oxo-1,4(2H)-benzoxazin-7-yl]-2,3,4,5-tetrahydro-5-methylpyridazin-3-one
bemoradan
bemorandan
6-(3,4-dihydro-3-oxo-1,4(2H)-benzoxazin-7-yl)-2,3,4,5-tetrahydro-5-methylpyridazin-3-one
RWJ 22867

Biological Activity

[Description]:

Bemoradan (compound 10a) is an orally active and selective canine Phosphodiesterase (PDE) fraction III inhibitor. Bemoradan is a long-acting, potent, inotropic vasodilator and a novel cardiotonic agent, and can be used in congestive heart failure research[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

[References]

[1]. Combs DW, et al. 6-Benzoxazinylpyridazin-3-ones: potent, long-acting positive inotrope and peripheral vasodilator agents. J Med Chem. 1990 Jan;33(1):380-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₃N₃O₃

[ Molecular Weight ]:
259.26

[ Exact Mass ]:
259.09600

[ PSA ]:
79.79000

[ LogP ]:
0.78000

Related Compounds

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