Octadecyltrimethylammonium bromide

Names

[ Name ]:
Octadecyltrimethylammonium bromide

[Synonym ]:
Octadecy trimethyl ammonium bromide
trimethyl(octadecyl)azanium,bromide
EINECS 214-294-5
Trimethyloctadecylammonium bromide
Octadecyltrimethylammonium bromide
1-Octadecanaminium, N,N,N-trimethyl-, bromide
1-Octadecanaminium, N,N,N-trimethyl-, bromide (1:1)
N,N,N-Trimethyloctadecan-1-aminium bromide
N,N,N-Trimethyl-1-octadecanaminium bromide
MFCD00043171
Trimethylstearylammonium Bromide

Biological Activity

[Description]:

Trimethyloctadecylammonium bromide is an inhibitor of dynamin, with an IC50 value of 1.9 μM for dynamin I. Trimethyloctadecylammonium bromide exhibits antibacterial activity against Staphylococcus aureus[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Cytoskeleton >> Dynamin

[Target]

IC50: 1.9 μM (Dynamin I)[1]

[In Vitro]

Trimethyloctadecylammonium bromide (1 μM-100 μM; 10 min) inhibits EGF-A488 endocytosis in COS-7 cells, with an IC50 value of 16 μM[1]. Trimethyloctadecylammonium bromide (30 μM; 10 min; 37 ℃) shows no effect on EGFR activation in A431 cells with insignificant EGFR autophosphorylation change[1]. Trimethyloctadecylammonium bromide (stearyl-) (1 nM-1 mM) inhibits Staphylococcus aureus with of 59.5 nM (CKD assay) and 0.33 mM (CMC assay), respectively[2].

Chemical & Physical Properties

[ Melting Point ]:
~250 °C (dec.)(lit.)

[ Molecular Formula ]:
C₂₁H₄₆BrN

[ Molecular Weight ]:
392.501

[ Exact Mass ]:
391.281342

[ LogP ]:
3.95810

[ Stability ]:
Stable. Hygroscopic. Incompatible with strong oxidizing agents. Protect from moisture.

[ Water Solubility ]:
soluble

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2923900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2923900090

[ Summary ]:
2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Regular self-motion of a liquid droplet powered by the chemical marangoni effect.

Colloids Surf. B Biointerfaces 56(1-2) , 197-200, (2007)

We describe here our recent work on spontaneous regular motion of liquid droplet powered by the chemical Marangoni effect under spatially symmetric conditions. It is shown that a spontaneously crawlin...

Spontaneous deformation of an oil droplet induced by the cooperative transport of cationic and anionic surfactants through the interface.

J. Phys. Chem. B 113(48) , 15709-14, (2009)

Spontaneous deformation of a tetradecane droplet with palmitic acid on an aqueous phase with stearyltrimethylammonium chloride is reported. Palmitic acid is transported from the oil droplet to the aqu...

Removal of non-ionic organic pollutants from water via liquid-liquid extraction.

Water Res. 39(9) , 1907-1913, (2005)

The removal of model pollutants bromocresol green (BG) and phenol from water is demonstrated via two liquid-liquid extraction methods. Both methods exploit selective interactions established by the po...

Related Compounds

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