Adenanthin

Names

[ CAS No. ]:
111917-59-0

[ Name ]:
Adenanthin

[Synonym ]:
(1α,3β,5β,7β,8α,9β,10α,11β)-3-Hydroxy-6,15-dioxokaur-16-ene-1,7,11-triyl triacetate

Biological Activity

[Description]:

Adenanthin is an inhibitor of thiol-dependent antioxidant enzymes, targeting to Prx 1 and Prx 2. Adenanthin impairs human natural killer (NK) cells effector functions, and killing hepatocellular carcinoma cells. Adenanthin inhibits NF-κB signaling and lipogenesis and the development of obesity by regulating ROS[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

[Target]

Prx 1, Prx 2, NF-κB[1]

[References]

[1]. Hu J, et al. Adenanthin, a Natural ent-Kaurane Diterpenoid Isolated from the Herb Isodon adenantha Inhibits Adipogenesis and the Development of Obesity by Regulation of ROS. Molecules. 2019 Jan 3;24(1):158.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
593.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₆H₃₄O₉

[ Molecular Weight ]:
490.543

[ Flash Point ]:
192.6±23.6 °C

[ Exact Mass ]:
490.220276

[ PSA ]:
133.27000

[ LogP ]:
1.36

[ Vapour Pressure ]:
0.0±3.8 mmHg at 25°C

[ Index of Refraction ]:
1.550

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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