SAR125844

Names

[ Name ]:
SAR125844

[Synonym ]:
1-(6-{[6-(4-Fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)-3-[2-(4-morpholinyl)ethyl]urea
Urea, N-[6-[[6-(4-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]-2-benzothiazolyl]-N'-[2-(4-morpholinyl)ethyl]-

Biological Activity

[Description]:

SAR125844 is a potent, highly selective, reversible and ATP-competitive MET receptor tyrosine kinase (RTK) inhibitor for intravenous administration, with an IC50 of 4.2 nM. Shows inhibition of MET autophosphorylation in cell-based assays[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR

[Target]

IC50: 4.2 nM (MET RTK)[1].

[References]

[1]. Egile C, et al. The selective intravenous inhibitor of the MET tyrosine kinase SAR125844 inhibits tumor growth in MET-amplified cancer. Mol Cancer Ther. 2015 Feb;14(2):384-94.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C₂₅H₂₃FN₈O₂S₂

[ Molecular Weight ]:
550.631

[ Exact Mass ]:
550.136963

[ PSA ]:
163.11000

[ LogP ]:
3.86

[ Index of Refraction ]:
1.781

[ Storage condition ]:
2-8℃

Related Compounds

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