Ristomycin sulfate

Names

[ Name ]:
Ristomycin sulfate

[Synonym ]:
RISTOCETIN A SULFATE
Methyl (1S,2R,18R,19R,22R,34S,37R,40R)-22-amino-2-[(3-amino-2,3,6-trideoxy-α-L-ribo-hexopyranosyl)oxy]-64-{[β-D-arabinopyranosyl-(1->2)-D-mannopyranosyl-(1->2)-[6-deoxy-α-L-mannopyranosyl-( 1->6)]-β-D-glucopyranosyl]oxy}-18,26,31,44,49-pentahydroxy-47-(β-D-mannopyranosyloxy)-30-methyl-21,35,38,54,56,59-hexaoxo-7,13,28-trioxa-20,36,39,53,55,58-hexaazaundecacyclo[38.14.2.2.2.2.1.1.1.1~41,
Ristocetin sulfate salt
RISTOMYCIN MONOSULFATE
RISTOCETINSULFATQ
Ristocetin A sulphate
RISTOCETIN SULFATE
RISTOMYCIN
SPONTIN
ristomycin,sulfate
RISTON

Biological Activity

[Description]:

Ristomycin sulfate is a glycopeptide antibiotic isolated from Nocardia lurida[1].

[Related Catalog]:

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

[References]

[1]. M C Berndt, et al. Ristocetin-dependent reconstitution of binding of von Willebrand factor to purified human platelet membrane glycoprotein Ib-IX complex. Biochemistry. 1988 Jan 26;27(2):633-40.

Chemical & Physical Properties

[ Molecular Formula ]:
C₉₅H₁₁₀N₈O_44.H₂SO₄

[ Molecular Weight ]:
2165.996

[ Exact Mass ]:
2164.628906

[ PSA ]:
899.20000

[ Storage condition ]:
-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VJ8650000

CHEMICAL NAME :: Ristomycin, sulfate

CAS REGISTRY NUMBER :: 11140-99-1

LAST UPDATED :: 198903

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 660 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - excitement Lungs, Thorax, or Respiration - other changes

REFERENCE :: AMBIEH Antibiotiki i Meditsinskaya Biotekhnologiya. Antibiotics and Medical Biotechnology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.30-V.32, 1985-1987 Volume(issue)/page/year: 32,910,1987

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/38

[ Safety Phrases ]:
22-24/25-37/39-26

[ RIDADR ]:
UN 3249

[ RTECS ]:
VJ8650000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Articles

Overproduction of Ristomycin A by activation of a silent gene cluster in Amycolatopsis japonicum MG417-CF17.

Antimicrob. Agents Chemother. 58(10) , 6185-96, (2014)

The emergence of antibiotic-resistant pathogenic bacteria within the last decades is one reason for the urgent need for new antibacterial agents. A strategy to discover new anti-infective compounds is...

Jordan, D.C., D. Gottlieb and P. Shaw,, ed.

Antibiotics New York , (1967) 1 , 84

Ristocetin- and thrombin-induced platelet aggregation at physiological shear rates: differential roles for GPIb and GPIIb-IIIa receptor.

Thromb. Haemost. 80 , 428-436, (1998)

We recently reported that washed platelets (WP) activated with ADP and expressing surface-bound vWF aggregated in flow through small tubes or in a cylindrical couette device at physiological shear rat...

Related Compounds

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