Funiculosine

Names

[ Name ]:
Funiculosine

[Synonym ]:
funiculosin
Funiculosine
Funiculosin (pyridone)
3-[(6S)-6-[(E,4S,6R)-4,6-dimethyloct-2-en-2-yl]-5-methyl-3,6-dihydro-2H-pyran-2-yl]-2-hydroxy-1-methyl-5-[(2R,3R,4S,5R)-2,3,4,5-tetrahydroxycyclopentyl]pyridin-4-one
4-hydroxy-1-methyl-3-[(2R)-5-methyl-6c-((1E,3R,5R)-1,3,5-trimethyl-hept-1-enyl)-3,6-dihydro-2H-pyran-2r-yl]-5-(2c,3c,4c,5c-tetrahydroxy-cyclopent-r-yl)-1H-pyridin-2-one
Funiculosin (antibiotic)
2(1H)-Pyridinone,3-(3,6-dihydro-5-methyl-6-(1,3,5-trimethyl-1-heptenyl)-2H-pyran-2-yl)-4-hydroxy-1-methyl-5-(2,3,4,5-tetrahydroxycyclopentyl)-,stereoisomer

Biological Activity

[Description]:

Funiculosin is a neutral lipophilic antibiotic that inhibits DNA and RNA viruses. Funiculosin also has antifungal activity. Funiculosin inhibits infections caused by pathogenic fungi in primary chicken embryo fibroblasts[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

[References]

[1]. Ando K, et al. Funiculosin, a new antibiotic. I. Isolation, biological and chemical properties (studies on antiviral and antitumor antibiotics. 8). J Antibiot (Tokyo). 1969 May;22(5):189-94.

Chemical & Physical Properties

[ Density]:
1.278g/cm3

[ Boiling Point ]:
623ºC at 760mmHg

[ Molecular Formula ]:
C₂₇H₄₁NO₇

[ Molecular Weight ]:
491.61700

[ Flash Point ]:
330.6ºC

[ Exact Mass ]:
491.28800

[ PSA ]:
132.38000

[ LogP ]:
2.42660

[ Vapour Pressure ]:
3.96E-18mmHg at 25°C

[ Index of Refraction ]:
1.606

Related Compounds

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