4-Desmethoxy Omeprazole

Names

[ Name ]:
4-Desmethoxy Omeprazole

[Synonym ]:
2-[[(3,5-Dimethyl-2-pyridinyl)methyl]sulfinyl]-6-methoxy-1H-benzimidazole
2-(((3,5-Dimethylpyridin-2-yl)methyl)sulfinyl)-5-methoxy-1H-benzo[d]imidazole
Omeprazole impurity B [EP]
4-Desmethoxy Omeprazole
UNII:0S4HQG5KFN
UNII-0S4HQG5KFN
1H-Benzimidazole, 2-[[(3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-5-methoxy-
2-{[(3,5-Dimethyl-2-pyridinyl)methyl]sulfinyl}-5-methoxy-1H-benzimidazole
Omeprazole magnesium impurity B [EP]
Esomeprazole Impurity 2

Biological Activity

[Description]:

4-Desmethoxy Omeprazole is the active metabolite of Omeprazole. Omeprazole, a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Research Areas >> Metabolic Disease

[References]

[1]. Li XQ, et al. Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos. 2004 Aug;32(8):821-7.

[2]. Jonkers D, et al. Omeprazole inhibits growth of gram-positive and gram-negative bacteria including Helicobacter pylori in vitro. J Antimicrob Chemother. 1996 Jan;37(1):145-50.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
584.7±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₇N₃O₂S

[ Molecular Weight ]:
315.390

[ Flash Point ]:
307.4±32.9 °C

[ Exact Mass ]:
315.104156

[ PSA ]:
87.08000

[ LogP ]:
1.90

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.687

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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