U73975

Names

[ CAS No. ]:
110314-48-2

[ Name ]:
U73975

Biological Activity

[Description]:

https://pubmed.ncbi.nlm.nih.gov/1624543/

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

Adolezesin (U73975; 0-50 pg/mL; 90 min) 抑制 ATP 含量，对 SKUT1B、AN3、AE7、HEC1A 和 BG1 的 IC50 分别为 0.097、0.14、0.36、0.53 和 1.65 pg/mL[1]。 Adolezesin (0-50 pg/mL; 0-168 h) 阻断 SKUT1B 细胞 S 期和 G2 期细胞周期[1]。 Cell Cycle Analysis[1] Cell Line: SKUT1B Concentration: 1, 2, 5, 10 and 50 pg/mL Incubation Time: 0-168 h Result: Blocks cell cycle at S and G2 phases at 50 pg/mL in SKUT1B cells.

[References]

[1]. Nguyen HN, et al. Spectrum of cell-cycle kinetics of alkylating agent adolezesin in gynecological cancer cell lines: correlation with drug-induced cytotoxicity. J Cancer Res Clin Oncol. 1992;118(7):515-22.

Chemical & Physical Properties

[ Density]:
1.56g/cm3

[ Boiling Point ]:
766.2ºC at 760mmHg

[ Molecular Formula ]:
C₃₀H₂₂N₄O₄

[ Molecular Weight ]:
502.52000

[ Flash Point ]:
417.2ºC

[ Exact Mass ]:
502.16400

[ PSA ]:
111.20000

[ LogP ]:
5.30770

[ Index of Refraction ]:
1.816

Related Compounds

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