m-PEG5-Propyne

Names

[ CAS No. ]:
1101668-41-0

[ Name ]:
m-PEG5-Propyne

Biological Activity

[Description]:

m-PEG5-Propyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1006.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₂₆O₆

[ Molecular Weight ]:
290.35

m-PEG5-Propyne

Names

Biological Activity

Chemical & Physical Properties

Related Compounds