m-PEG4-propargyl

Names

[ CAS No. ]:
1101668-39-6

[ Name ]:
m-PEG4-propargyl

[Synonym ]:
2,5,8,11,14-Pentaoxaheptadec-16-yne

Biological Activity

[Description]:

m-PEG4-propargyl is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
304.2±32.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₂H₂₂O₅

[ Molecular Weight ]:
246.300

[ Flash Point ]:
115.2±25.0 °C

[ Exact Mass ]:
246.146729

[ LogP ]:
-0.96

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.443

[ Storage condition ]:
2-8°C

Related Compounds

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