[Des-His1,Glu9] Glucagon

[Des-His1,Glu9] Glucagon is a potent glucagon receptor system peptide antagonist. [Des-His1,Glu9] Glucagon enhances the glucose-stimulated release of insulin from pancreatic islet cells. [Des-His1,Glu9] Glucagon can be used to research diabetes[1].

Research Areas >> Metabolic Disease

Glucagon Receptor[1]

[Des-His1,Glu9] Glucagon (1 pM-100 μM) does not activate membrane-bound adenylate cyclase up to a concentration of 2×10-4 molar in the cAMP assay on isolated rat liver membranes (from male Sprague Dawley rats)[1].

[Des-His1,Glu9] Glucagon (3.6-4.0 μg/kg for rabbits, 1 mg/kg for rats; i.v.; single dosage) suppresses hyperglycemic effects in rabbits and rats[1]. Animal Model: New Zealand rabbits (2.8-3.8 kg; fasted for 18 hours)[1] Dosage: 3.6-4.0 μg/kg Administration: i.v.; single dosage Result: Suppressed hyperglycemic response of glucagon. Animal Model: Male Wistar rats weighing [350-400 mg; hyperglycemia induced by i.p. injection of 65 mg/kg Streptozotocin (HY-13753)][1] Dosage: 1 mg/kg Administration: Intravenously administration through the tail vein; single dosage Result: Decreased blood glucose rapidly, and reduced hyperglycemic effect by 70% within 5 min.