Monazomycin

Monazomycin is a polyene-like antibiotic produced by Streptomyces. Monazomycin molecular weight is about 1200[1].

Research Areas >> Infection

Monazomycin is an antibiotic produced by Streptomyces. Its molecular weight is about 1200, and is related to that of polyene antibiotics. Monazomycin has an amino group that gives a positive charge to the molecule at neutral pH. When monazomycin is added in micromolar amounts to one side of a bilayer, membrane conductance becomes strongly voltage-dependent. Monazomycin is present in the solution in the form of relatively hydrophilic clusters and is adsorbed as such on top of the lipid bilayer, penetration into the bilayer following a potential jump is assumed to be preceded by a potential-independent disaggregation of the adsorbed clusters into adsorbed monomers[1].

[1]. Becucci L, et al. Kinetics of channel formation in bilayer lipid membranes (BLMs) and tethered BLMs: monazomycin and melittin. Langmuir. 2007;23(10):5601-5608.