PLpro inhibitor

Names

[ Name ]:
PLpro inhibitor

[Synonym ]:
5-acetamido-2-methyl-N-[2-(1-naphthalenyl)ethyl]benzamide
PLpro inhibitor
5-acetylamino-2-methyl-N-[(R)-1-(1-naphthyl)ethyl]benzamide
I06-1404
5-N-Acetylamino-2-methyl-N-[(R)-1-(1-naphthyl)ethyl]benzamide

Biological Activity

[Description]:

PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with IC50 of 2.6 uM.IC50 Value: 2.6 uM [1]Target: PLpro; SARS-CoVin vitro: PLpro inhibitor is a potent inhibitor against the papain-like protease (PLpro) from the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). PLpro inhibitor was found to have IC50 value of 2.6 ± 0.1 μM. PLpro inhibitor display significant antiviral activity with EC50 values of 13.1±0.7 uM, without toxicity up to the highest concentration tested. Notably, the increasing antiviral potency correlates with the in vitro inhibition of PLpro, suggesting that the compounds work directly on the enzyme in cells [1,2].in vivo:

[Related Catalog]:

Signaling Pathways >> Anti-infection >> SARS-CoV

Research Areas >> Infection

[References]

[1]. Ratia, K., et al., A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc Natl Acad Sci U S A, 2008. 105(42): p. 16119-24.

[2]. http://www.google.com/patents/WO2010022355A1cl=en

[Related Small Molecules]

Remdesivir

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₂N₂O₂

[ Molecular Weight ]:
346.42200

[ Exact Mass ]:
346.16800

[ PSA ]:
65.18000

[ LogP ]:
5.30340

[ Storage condition ]:
2-8℃

Related Compounds

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