MM 419447

Names

[ Name ]:
MM 419447

Biological Activity

[Description]:

MM 419447, a linaclotide metabolite, is a guanylate cyclase-C agonist. MM 419447 has the potential for the research of the irritable bowel syndrome with constipation (IBS-C)[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

Signaling Pathways >> GPCR/G Protein >> Guanylate Cyclase

[In Vitro]

MM 419447 exhibits high-affinity binding to T84 cells, resulting in a significant, concentration-dependent accumulation of intracellular cyclic guanosine-39,59-monophosphate (cGMP)[1].

[In Vivo]

MM 419447 (10 mg/kg; p.o.) treatment shows the Cmax, AUC0-6 and t1/2 values of 27 ng/mL, ≤ 29.7 ng h/mL and 0.33 hours, respectively[1] Animal Model: Female Sprague-Dawley rats[1] Dosage: 10 mg/kg Administration: P.o. (Pharmacokinetic Analysis) Result: The Cmax, AUC0-6 and Tmax were 27 ng/mL, ≤ 29.7 ng h/mL and 0.33 hours, respectively.

[References]

[1]. Busby RW, et al. Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation. J Pharmacol Exp Ther. 2013;344(1):196-206.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₀H₇₀N₁₄O₁₉S₆

[ Molecular Weight ]:
1363.56

Related Compounds

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