Caffeoyltryptophan

Names

[ Name ]:
Caffeoyltryptophan

[Synonym ]:
L-Tryptophan, N-[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]-
N-[(2E)-3-(3,4-Dihydroxyphenyl)-2-propenoyl]-L-tryptophan

Biological Activity

[Description]:

Caffeoyltryptophan is a competitive PTP1B inhibitor, with an IC50 of 16.99 μM. Caffeoyltryptophan can also inhibit α-glucosidase, linoleic acid peroxidation and haemolysis. Caffeoyltryptophan can be used for the research of type 2 diabetes[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

Research Areas >> Metabolic Disease

[References]

[1]. Ha MT, et, al. PTP1B and α-glucosidase inhibitory activities of the chemical constituents from Hedera rhombea fruits: Kinetic analysis and molecular docking simulation. Phytochemistry. 2022 May:197:113100.

[2]. Ohnishi M, et, al. Inhibition in vitro linoleic acid peroxidation and haemolysis by caffeoyltryptophan. Phytochemistry. 1998 Apr;47(7):1215-8.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
771.3±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₁₈N₂O₅

[ Molecular Weight ]:
366.367

[ Flash Point ]:
420.3±32.9 °C

[ Exact Mass ]:
366.121582

[ LogP ]:
2.11

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.745

Related Compounds

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