Z62954982

Names

[ Name ]:
Z62954982

[Synonym ]:
3-[(3,5-Dimethyl-1,2-oxazol-4-yl)methoxy]-N-(4-methyl-3-sulfamoylphenyl)benzamide
Benzamide, N-[3-(aminosulfonyl)-4-methylphenyl]-3-[(3,5-dimethyl-4-isoxazolyl)methoxy]-

Biological Activity

[Description]:

Z62954982 is a potent, specific Rac1 inhibitor, reduces the intracellular levels of Rac1-GTP in a concentration-dependent manner with IC50 of 12 uM, 4 times more effective than NSC23766 (IC50=50 uM); causes a concentration-dependent decrease in transendothelial electrical resistance (TER) in both HDMEC and HUVEC.

[References]

References 1. Zhang XE, et al. PLoS One. 2016 May 17;11(5):e0155490. 2. Lobastova L, et al. Cell Oncol (Dordr). 2017 Feb;40(1):63-76. 3. Yamaguchi N, et al. Sci Rep. 2015 Jan 7;5:7656. 4. Ferri N, et al. J Med Chem. 2009 Jul 23;52(14):4087-90. View Related Products by Target Small GTPase

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₂₀H₂₁N₃O₅S

[ Molecular Weight ]:
415.463

[ Exact Mass ]:
415.120178

[ LogP ]:
1.49

[ Index of Refraction ]:
1.618

Related Compounds

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