2-Pipecoline

Names

[ CAS No. ]:
109-05-7

[ Name ]:
2-Pipecoline

[Synonym ]:
Piperidine,2-methyl
2-METHYLPIPERIDIN
α-Pipecolin
Pipicoline
2-Pipecoline
EINECS 203-642-1
2-Pipecoline (8CI)
Piperidine, 2-methyl-
2-METHYL PIPERIDINE
2-METHYL-PIPERIDINE
2-METHYLPIPERIDINE FOR SYNTHESIS
2-METHYLPIPERIDINE/2-PIPECOLINE
2-Methylpiperidine
α-Pipecoline
MFCD00005982

Chemical & Physical Properties

[ Density]:
0.8±0.1 g/cm3

[ Boiling Point ]:
118.8±0.0 °C at 760 mmHg

[ Melting Point ]:
-4--5 °C

[ Molecular Formula ]:
C₆H₁₃N

[ Molecular Weight ]:
99.174

[ Flash Point ]:
8.3±0.0 °C

[ Exact Mass ]:
99.104797

[ PSA ]:
12.03000

[ LogP ]:
1.42

[ Vapour Pressure ]:
16.4±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.422

[ Storage condition ]:
Flammables area

[ Water Solubility ]:
soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TN1240000

CHEMICAL NAME :: Piperidine, 2-methyl-

CAS REGISTRY NUMBER :: 109-05-7

BEILSTEIN REFERENCE NO. :: 0079804

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H13-N

MOLECULAR WEIGHT :: 99.20

WISWESSER LINE NOTATION :: T6MTJ B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BDCGAS Berichte der Deutschen Chemischen Gesellschaft. (Leipzig, Ger. Dem. Rep.) V.1-61, 1868-1928. For publisher information, see CHBEAM. Volume(issue)/page/year: 34,2408,1901 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84360 No. of Facilities: 5 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 20 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H302-H315-H318-H335

[ Precautionary Statements ]:
P210-P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F:Flammable;Xn:Harmful;

[ Risk Phrases ]:
R11;R22;R34

[ Safety Phrases ]:
S16-S26-S39-S45-S36/37/39

[ RIDADR ]:
UN 1993 3/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
TN1240000

[ Packaging Group ]:
II

[ Hazard Class ]:
3

[ HS Code ]:
29333999

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

C-2 arylation of piperidines through directed transition-metal-catalyzed sp3 C-H activation.

Chemistry 16 , 13063-13067, (2010)

Gold-catalyzed efficient synthesis of azepan-4-ones via a two-step [5 + 2] annulation.

Chem. Commun. (Camb.) 46 , 3351-3353, (2010)

A surprisingly efficient synthesis of azepan-4-ones via a two-step [5 + 2] annulation is developed. This reaction involves a key gold catalysis and shows generally high regioselectivities and good to ...

Acetoacetanilides as masked isocyanates: facile and efficient synthesis of unsymmetrically substituted ureas.

Org. Lett. 12 , 4220-4223, (2010)

A general and practical method for the preparation of unsymmetrically substituted ureas has been developed. By the reactions of acetoacetanilides with various amines including primary/secondary amines...