Ilexsaponin A

Names

[ Name ]:
Ilexsaponin A

[Synonym ]:
1-O-[(3β,5ξ)-3,19,23-Trihydroxy-23,28-dioxours-12-en-28-yl]-β-D-glucopyranose
β-D-Glucopyranose, 1-O-[(3β,5ξ)-3,19,23-trihydroxy-23,28-dioxours-12-en-28-yl]-
Ilexsaponin A1

Biological Activity

[Description]:

Ilexsaponin A, isolated from the root of Ilex pubescens, attenuates ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway. Ilexsaponin A can reduce myocardial infarct size, lower the serum levels of LDH, AST and CK-MB, increase cellular viability and inhibit apoptosis in hypoxia/reoxygenation cardiomyocytes[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

[In Vitro]

Ilexsaponin A significantly reduces proapoptotic proteins including caspase-3, cleaved caspase-3 and bax and increases anti-apoptotic protein bcl-2 in hypoxia/reoxygenation cardiomyocytes. Ilexsaponin A treatment increases the expression levels of p-Akt in hypoxia/reoxygenation cellular model and myocardial ischemia/reperfusion animal model[1].

[In Vivo]

Ilexsaponin A (10 or 40 mg/kg) reduce the myocardial infarct size in a dose dependent manner in male Sprague-Dawley rats weighing 280-320 g[1].

[References]

[1]. Zhang SW, et al. Ilexsaponin A attenuates ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway. PLoS One. 2017 Feb 9;12(2):e0170984.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
788.1±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₆H₅₆O₁₁

[ Molecular Weight ]:
664.823

[ Flash Point ]:
240.1±26.4 °C

[ Exact Mass ]:
664.382263

[ LogP ]:
5.11

[ Vapour Pressure ]:
0.0±6.2 mmHg at 25°C

[ Index of Refraction ]:
1.611

[ Storage condition ]:
2-8℃

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ RIDADR ]:
UN 2811 6.1 / PGIII

Related Compounds

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