Malonamide
Names
[ CAS No. ]:
108-13-4
[ Name ]:
Malonamide
[Synonym ]:
Malonamide
Methylenebisformamide
Propanediamide
METHYLENEDIFORMAMIDE
Malondiamide
EINECS 203-553-8
MFCD00008034
Malonic acid diamide
MALONIC DIAMIDE
Malonodiamide
Malonyldiamide
Carboxamidoacetamide
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
460.9±28.0 °C at 760 mmHg
[ Melting Point ]:
172-175 °C(lit.)
[ Molecular Formula ]:
C3H6N2O2
[ Molecular Weight ]:
102.092
[ Flash Point ]:
232.5±24.0 °C
[ Exact Mass ]:
102.042931
[ PSA ]:
86.18000
[ LogP ]:
-2.54
[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C
[ Index of Refraction ]:
1.491
[ Water Solubility ]:
180 g/L (20 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- ON9125000
- CHEMICAL NAME :
- Malonamide
- CAS REGISTRY NUMBER :
- 108-13-4
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C3-H6-N2-O2
- MOLECULAR WEIGHT :
- 102.11
- WISWESSER LINE NOTATION :
- ZV1VZ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6 gm/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- REFERENCE :
- BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906- Volume(issue)/page/year: 34,1196,1940
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,1383,1977
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
C
[ Safety Phrases ]:
S22-S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
2
[ RTECS ]:
ON9125000
[ HS Code ]:
29241900
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2924199090
[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
Biomaterials 56 , 187-97, (2015)
Macrophage reprogramming has long been the focus of research in disease therapeutics and biomaterial implantation. With different chemical and physical properties of materials playing a role in macrop...
Influence of Ligand Shell Composition upon Interparticle Interactions in Multifunctional Nanoparticles.Langmuir 31 , 12742-52, (2015)
The interactions of nanoparticles with biomolecules, surfaces, or other nanostructures are dictated by the nanoparticle's surface chemistry. Thus, far, shortcomings of syntheses of nanoparticles with ...
Effect of surface modification and macrophage phenotype on particle internalization.Biomacromolecules 15(11) , 4102-10, (2014)
Material properties play a key role in the cellular internalization of polymeric particles. In the present study, we have investigated the effects of material characteristics such as water contact ang...