Ganodermanondiol

Names

[ Name ]:
Ganodermanondiol

[Synonym ]:
( )-Ganodermanondiol
Lanosta-7,9(11)-dien-3-one, 24,25-dihydroxy-, (24S)-
Lanost-7,9(11)-dien-3-one-,24,25-dihydroxy-(24S)
Lanosta-7,9(11)-dien-3-one,24,25-dihydroxy-,(24S)
(24S)-24,25-Dihydroxylanosta-7,9(11)-dien-3-one
Ganodermanondiol

Biological Activity

[Description]:

Ganodermanondiol is a melanogenesis inhibitor isolated from the Ganoderma lucidum[1].Ganodermanondiol exhibits potent cytoprotective effects on tert-butyl hydroperoxide-induced hepatotoxicity[2]. Ganodermanondiol shows significant anti-HIV-1 protease activity with an IC50 of 90 μM[3]. Ganodermanondiol exhibits a strong anticomplement activity against the classical pathway of the complement system with an IC50 of 41.7μM[4].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Protease

[Target]

IC50: 90μM (HIV-1 protease)[3]

[References]

[1]. Kim JW, et al. Effects of Ganodermanondiol, a New Melanogenesis Inhibitor from the Medicinal Mushroom Ganoderma lucidum. Int J Mol Sci. 2016 Oct 27;17(11).

[2]. Li B, et al. Protective effect of ganodermanondiol isolated from the Lingzhi mushroom against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2-mediated antioxidant enzymes. Food Chem Toxicol. 2013 Mar;53:317-24.

[3]. Min BS, et al. Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease. Chem Pharm Bull (Tokyo). 1998 Oct;46(10):1607-12.

[4]. Min BS, et al. Anticomplement activity of terpenoids from the spores of Ganoderma lucidum. Planta Med. 2001 Dec;67(9):811-4.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
580.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₀H₄₈O₃

[ Molecular Weight ]:
456.700

[ Flash Point ]:
318.9±26.6 °C

[ Exact Mass ]:
456.360352

[ PSA ]:
57.53000

[ LogP ]:
6.64

[ Vapour Pressure ]:
0.0±3.7 mmHg at 25°C

[ Index of Refraction ]:
1.547

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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