CD 1530

Names

[ Name ]:
CD 1530

[Synonym ]:
cd 1530

Biological Activity

[Description]:

CD1530 is a selective RARγ agonist with an Kd of 150 nM[1]. CD1530 has been used in combination with bexarotene to inhibit oral carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide in a mouse model of human oral-cavity and esophageal squamous-cell carcinoma[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR

[Target]

RARγ:150 nM (Kd)

[References]

[1]. Bernard BA, et al. Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma. Biochem Biophys Res Commun. 1992 Jul 31;186(2):977-83.

[2]. Tang XH, et al. Combination of bexarotene and the retinoid CD1530 reduces murine oral-cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8907-12.

Chemical & Physical Properties

[ Density]:
1.29g/cm3

[ Boiling Point ]:
610.7ºC at 760 mmHg

[ Molecular Formula ]:
C₂₇H₂₆O₃

[ Molecular Weight ]:
398.49400

[ Flash Point ]:
337.2ºC

[ Exact Mass ]:
398.18800

[ PSA ]:
57.53000

[ LogP ]:
6.37840

[ Vapour Pressure ]:
9.03E-16mmHg at 25°C

[ Index of Refraction ]:
1.688

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.