4-Hydroxythioanisole
Names
[ CAS No. ]:
1073-72-9
[ Name ]:
4-Hydroxythioanisole
[Synonym ]:
4-(Methylmercapto)phenol
4-Hydroxythioanisole
4-(Methylthio)phenol
4-methylsulfanylphenol
MFCD08443600
QR DS1
4-(Hydroxy)thioanisole
p-Hydroxythioanisole
p-(Methylthio)phenol
Phenol, 4-(methylthio)-
EINECS 214-031-4
Phenol, p-(methylthio)-
4-(Methylsulfanyl)phenol
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
269.7±0.0 °C at 760 mmHg
[ Melting Point ]:
84-86(lit.)
[ Molecular Formula ]:
C7H8OS
[ Molecular Weight ]:
140.203
[ Flash Point ]:
127.7±21.3 °C
[ Exact Mass ]:
140.029587
[ PSA ]:
45.53000
[ LogP ]:
1.81
[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C
[ Index of Refraction ]:
1.613
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SM1578500
- CHEMICAL NAME :
- Phenol, p-(methylthio)-
- CAS REGISTRY NUMBER :
- 1073-72-9
- BEILSTEIN REFERENCE NO. :
- 2041507
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C7-H8-O-S
- MOLECULAR WEIGHT :
- 140.21
- WISWESSER LINE NOTATION :
- QR DS1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intracerebral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 60 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971- Volume(issue)/page/year: 8,302,1978 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 8480 ng/kg/12D-I
- TOXIC EFFECTS :
- Liver - other changes Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
- REFERENCE :
- BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 45,935,1982
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36
[ RIDADR ]:
UN 3335
[ WGK Germany ]:
3
[ RTECS ]:
SM1578500
[ HS Code ]:
2930909090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2930909090
[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
Appl. Environ. Microbiol. 49(1) , 236-7, (1985)
Oxygen-limited cultures of Klebsiella pneumoniae reduced 4-methylsulfinyl phenol to 4-methylthiophenol. A study of the effect of 4-methylthiophenol on the growth of K. pneumoniae revealed that the spe...
Transition-metal-free highly efficient aerobic oxidation of sulfides to sulfoxides under mild conditions.Molecules 15(1) , 83-92, (2010)
A highly efficient transition-metal-free catalytic system Br2/NaNO2/H2O has been developed for a robust and economic acid-free aerobic oxidation of sulfides. It is noteworthy that the sulfide function...
Dimerization of ionized 4-(methyl mercapto)-phenol during ESI, APCI and APPI mass spectrometry.J. Mass Spectrom. 44(9) , 1389-94, (2009)
A novel ion/molecule reaction was observed to occur under electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI), and atmospheric pressure photo ionization (APPI) conditions, l...