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SM-433

Names

[ CAS No. ]:
1071992-81-8

[ Name ]:
SM-433

[Synonym ]:
unii-n65wc8pxdd

Biological Activity

[Description]:

SM-433, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs). SM-433 exhibits strong binding affinity XIAP BIR3 protein with an IC50<1 μM. (patent WO2008128171A2)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Apoptosis >> IAP

[In Vitro]

SM-433 exhibits strong inhibitory activity against MDA-MB -2131 human breast cancer cells and SK-OV-3 ovarian cancer cells (IC50s<10 μM, respectively)[1].

[References]

[1]. Shaomeng Wang, et al. Diazo bicyclic smac mimetics and the uses thereof. WO2008128171A2.

Chemical & Physical Properties

[ Molecular Formula ]:
C32H43N5O4

[ Molecular Weight ]:
561.71

[ Exact Mass ]:
561.33200

[ PSA ]:
117.83000

[ LogP ]:
4.64780


Related Compounds

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