N-Hydroxysulfosuccinimide sodium

Names

[ Name ]:
N-Hydroxysulfosuccinimide sodium

[Synonym ]:
3-Pyrrolidinesulfonic acid, 1-hydroxy-2,5-dioxo-, sodium salt (1:1)
Sodium 1-hydroxy-2,5-dioxopyrrolidine-3-sulfonate
Hydroxy-2,5-dioxopyrrolidine-3-sulfonicacid sodium salt
N-Hydroxysulfosuccinimide sodiumsalt
Sodium 1-hydroxy-2,5-dioxo-3-pyrrolidinesulfonate
sodium,1-hydroxy-2,5-dioxopyrrolidine-3-sulfonate
N-Hydroxysulfosuccinimide Sodium Salt
MFCD00217065

Biological Activity

[Description]:

N-Hydroxysulfosuccinimide (sodium) is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Non-cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Melting Point ]:
250 °C (dec.)(lit.)

[ Molecular Formula ]:
C₄H₄NNaO₆S

[ Molecular Weight ]:
217.132

[ Exact Mass ]:
216.965698

[ PSA ]:
123.19000

[ Storage condition ]:
0-6°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2925190090

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

The identification of a novel SIRT6 modulator from Trigonella foenum-graecum using ligand fishing with protein coated magnetic beads.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 968 , 105-11, (2014)

SIRT6 is a histone deacetylase that has been proposed as a potential therapeutic target for metabolic disorders and the prevention of age-associated diseases. Thus the identification of compounds that...

Pd-Ir Core-Shell Nanocubes: A Type of Highly Efficient and Versatile Peroxidase Mimic.

ACS Nano 9 , 9994-10004, (2015)

Peroxidase mimics with dimensions on the nanoscale have received great interest as emerging artificial enzymes for biomedicine and environmental protection. While a variety of peroxidase mimics have b...

Interprotein Coupling Enhances the Electrocatalytic Efficiency of Tobacco Peroxidase Immobilized at a Graphite Electrode.

Anal. Chem. 87 , 10807-14, (2015)

Covalent immobilization of enzymes at electrodes via amide bond formation is usually carried out by a two-step protocol, in which surface carboxylic groups are first activated with the corresponding c...

Related Compounds

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