CBP/p300-IN-21

Names

[ CAS No. ]:
1065581-69-2

[ Name ]:
CBP/p300-IN-21

Biological Activity

[Description]:

CBP/p300-IN-21 (Compound 5d) is a selective CBP/p300 inhibitor (IC50: 0.07 and 1.755 μM for p300 and CBP). CBP/p300-IN-21 decreases H3K18Ac level. CBP/p300-IN-21 inhibits growth of 4T1 tumor growth in mice[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> Histone Acetyltransferase
Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[Target]

0.07 and 1.755 μM for p300 and CBP[1]


[References]

[1]. Zhong X, et al. Discovery of berberine analogs as potent and highly selective p300/CBP HAT inhibitors. Bioorg Chem. 2023 Sep;138:106597.  

Chemical & Physical Properties

[ Molecular Formula ]:
C19H16ClNO4

[ Molecular Weight ]:
357.79

Related Compounds

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