Ganodermanontriol

Names

[ Name ]:
Ganodermanontriol

[Synonym ]:
Ganodermanontriol
Lanosta-7,9(11)-dien-3-one, 24,25,26-trihydroxy-, (24S,25R)-
(24S,25R)-24,25,26-Trihydroxylanosta-7,9(11)-dien-3-one

Biological Activity

[Description]:

Ganodermanontriol, a sterol isolated from Ganoderma lucidum, induces anti-inflammatory activity in tert-butyl hydroperoxide (t-BHP)-damaged hepatic cells through the expression of HO-1. Ganodermanontriol exhibits hepatoprotective activity[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

Ganodermanontriol inhibits breast cancer cell lines MCF-7 and MDA-MB-231with IC50 values of 5.8 and 9.7 μM, respectively[2].

[References]

[1]. Ha do T, et al. In vitro and in vivo hepatoprotective effect of ganodermanontriol against t-BHP-induced oxidative stress. Ethnopharmacol. 2013 Dec 12;150(3):875-85.

[2]. Kennedy EM, et al. Semisynthesis and biological evaluation of ganodermanontriol and its stereoisomeric triols. J Nat Prod. 2011 Nov 28;74(11):2332-7.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
623.2±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₀H₄₈O₄

[ Molecular Weight ]:
472.700

[ Flash Point ]:
344.7±28.0 °C

[ Exact Mass ]:
472.355255

[ PSA ]:
77.76000

[ LogP ]:
5.66

[ Vapour Pressure ]:
0.0±4.1 mmHg at 25°C

[ Index of Refraction ]:
1.559

Related Compounds

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