NSC 140873

Names

[ Name ]:
NSC 140873

[Synonym ]:
2-glycine amide-5-chlorophenyl 2-pyrryl ketone
GCPK

Biological Activity

[Description]:

NSC 140873 is an inhibitor of the RUNX1-CBFβ interaction. NSC 140873 can be used for research of viral infection and leukemia. NSC 140873 has an unstable structure and can be converted spontaneously in solution to a benzodiazepine (Ro5-3335)[1][2].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Others >> Others

[In Vitro]

NSC 140873 (1 至 100 μM，5-6 天) 降低斑马鱼胚胎中的确定性造血功能[2]。 NSC 140873 对高表达 RUNX1 的细胞具有抗增殖活性[2]。

[References]

[1]. Pu Liu, et al. Methods for treating leukemia and disorders mediated by cbfβ and runx1 proteins. Patent. WO2012125787A1.

[2]. Cunningham L, et al. Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14592-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₂ClN₃O₂

[ Molecular Weight ]:
277.71

[ Exact Mass ]:
277.06200

[ PSA ]:
91.47000

[ LogP ]:
3.14610

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.