Ro 22-9194

Names

[ CAS No. ]:
106134-33-2

[ Name ]:
Ro 22-9194

[Synonym ]:
Ro 22-9194

Biological Activity

[Description]:

Ro 22-9194 inhibits aggregation and thromboxane Az (TXA2) synthetase activity in rabbit and human platelets. Ro 22-9194 has a potent inhibitory action against various types of model arrhythmias. Ro 22-9194 has non-cholinergic cardiac depressant properties with its vasodilating action[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor

[References]

[1]. M Murakami, et al. Cardiovascular effects of 2-amino-N-(2,6-dimethylphenyl)-N-[3-(3-pyridyl)propyl]propionamide dihydrochloride (Ro 22-9194) in the isolated, cross-perfused atrium of the dog. Jpn Heart J. 1990 Sep;31(5):731-9.  

[2]. I Kodama, et al. Electropharmacology of Ro 22-9194, a new antiarrhythmic agent. Gen Pharmacol. 1996 Jul;27(5):755-60.  

Chemical & Physical Properties

[ Boiling Point ]:
494.1ºC at 760mmHg

[ Molecular Formula ]:
C19H27Cl2N3O

[ Molecular Weight ]:
384.34300

[ Flash Point ]:
252.6ºC

[ Exact Mass ]:
383.15300

[ PSA ]:
59.22000

[ LogP ]:
5.31570

[ Vapour Pressure ]:
6.62E-10mmHg at 25°C