MBP (1-11), guinea pig, porcine, rabbit, rat, Myelin Basic Protein (135-145), human,Ac-ASQKRPSQRHG

Names

[ Name ]:
MBP (1-11), guinea pig, porcine, rabbit, rat, Myelin Basic Protein (135-145), human,Ac-ASQKRPSQRHG

[Synonym ]:
myelin basic protein (135-145),human
ac-mbp (human,porcine,rat 1-11)
acetyl-mbp (135-145) (human)
mbp (1-11) human
acetyl-myelin a1 protein (135-145) (human)
acetyl-myelin basic protein (135-145) (human)
ac-asqkrpsqrhg
acetyl-golli-mbp1 hog7 (135-145) (human)
mbp (1-11),guinea pig,porcine,rabbit,rat
acetyl-myelin basic protein (human,rat,1-11)
Myelin Basic Protein (135-145)

Biological Activity

[Description]:

Myelin Basic Protein (1-11) is an encephalitogenic epitope of myelin basic protein (MBP). Myelin Basic Protein (1-11) can be used for induction of experimental autoimmune encephalomyelitis (EAE)[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

Myelin Basic Protein (1-11) (0-10 μg/mL) 刺激 MBP-TCR CD4 T 细胞产生 IL-2[1]。

[In Vivo]

Myelin Basic Protein (1-11) (100 μg/mL)-pulsed DC 细胞 (i.p.) 在转移到受照射的 B10.PL 小鼠体内时会诱导实验性自身免疫性脑脊髓炎 (EAE)[1]。 Myelin Basic Protein (1-11) (100 μg，腹腔注射) 诱导成年小鼠对 MBP 的耐受性并预防 MBP 诱导的 EAE[2]。

[References]

[1]. Dittel BN, et al. Presentation of the self antigen myelin basic protein by dendritic cells leads to experimental autoimmune encephalomyelitis. J Immunol. 1999 Jul 1;163(1):32-9.

[2]. Gaur A, et al. Amelioration of autoimmune encephalomyelitis by myelin basic protein synthetic peptide-induced anergy. Science. 1992 Nov 27;258(5087):1491-4.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₂H₈₈N₂₂O₁₇

[ Molecular Weight ]:
1293.39000

[ Exact Mass ]:
1292.67000

[ PSA ]:
653.75000

Related Compounds

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