Palmatine hydrochloride

Names

[ Name ]:
Palmatine hydrochloride

[Synonym ]:
Dibenzo[a,g]quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-, chloride (1:1)
Palmatine chloride
GNF-PF-4086
2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolinium chloride
Palmatine chloride,Palmatine hydrochloride
Palmatinehydrochloride
2,3,9,10-Tetramethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium chloride
Prestwick_374
Palmatine (chloride)

Biological Activity

[Description]:

Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties. IC50 value:Target:In vitro: Experimental set examined the influence of palmatine on osteoblast-like cells in vitro. In the culture supernatant of MC3T3-E1 cells, RANKL and OPG levels were significantly reduced by palmatine addition [1]. In vivo: The first experimentaI set was designed to histologically and biochemically examine mice randomly divided into four groups: sham-operated, OVX, and OVX-palmatine intake groups (1 mg/kg and 10 mg/kg). In palmatine-treated mice, RANKL and OPG expression decreased [1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Natural Products >> Alkaloid

Research Areas >> Others

[References]

[1]. SHINTARO ISHIKAWA, et al. Influence of Palmatine on Bone Metabolism in Ovariectomized Mice and Cytokine Secretion of Osteoblasts.

[2]. Chen-Wen Xiao, er al. Antifungal activity of berberine hydrochloride and palmatine hydrochloride against Microsporum canis -induced dermatitis in rabbits and underlying mechanism. BMC Complement Altern Med. 2015; 15: 177.

[Related Small Molecules]

Chemical & Physical Properties

[ Melting Point ]:
205 °C

[ Molecular Formula ]:
C₂₁H₂₂ClNO₄

[ Molecular Weight ]:
387.857

[ Exact Mass ]:
387.123749

[ PSA ]:
40.80000

[ LogP ]:
0.38880

[ Vapour Pressure ]:
6.6E-15mmHg at 25°C

[ Index of Refraction ]:
1.624

Safety Information

[ Risk Phrases ]:
20/22-36/38

[ Safety Phrases ]:
24/45

[ HS Code ]:
2933990090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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