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N,N'-Diethylthiourea

Names

[ CAS No. ]:
105-55-5

[ Name ]:
N,N'-Diethylthiourea

[Synonym ]:
1,3-diethylthiourea
MFCD00004925
1,3-Diethyl-2-thiourea
EINECS 203-308-5
N,N‘-Diethylthiourea
DETU

Chemical & Physical Properties

[ Density]:
1,12 g/cm3

[ Boiling Point ]:
169.2ºC at 760 mmHg

[ Melting Point ]:
76-78 °C(lit.)

[ Molecular Formula ]:
C5H12N2S

[ Molecular Weight ]:
132.22700

[ Flash Point ]:
186 °C

[ Exact Mass ]:
132.07200

[ PSA ]:
56.15000

[ LogP ]:
1.27210

[ Vapour Pressure ]:
1.56mmHg at 25°C

[ Index of Refraction ]:
1.505

[ Stability ]:
Stable. May be air sensitive. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
38 g/L (20 ºC)

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YS9800000
CHEMICAL NAME :
Urea, 1,3-diethyl-2-thio-
CAS REGISTRY NUMBER :
105-55-5
BEILSTEIN REFERENCE NO. :
0773905
LAST UPDATED :
199710
DATA ITEMS CITED :
15
MOLECULAR FORMULA :
C5-H12-N2-S
MOLECULAR WEIGHT :
132.25
WISWESSER LINE NOTATION :
SUYM1&M1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
316 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
62 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
11 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Endocrine - thyroid tumors

MUTATION DATA

TYPE OF TEST :
Morphological transformation
TEST SYSTEM :
Rodent - hamster Embryo
DOSE/DURATION :
550 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 356,85,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84809 No. of Facilities: 487 (estimated) No. of Industries: 6 No. of Occupations: 8 No. of Employees: 11186 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84809 No. of Facilities: 1141 (estimated) No. of Industries: 24 No. of Occupations: 28 No. of Employees: 11484 (estimated) No. of Female Employees: 739 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302 + H312-H317-H318-H372-H412

[ Precautionary Statements ]:
P260-P280-P301 + P312 + P330-P305 + P351 + P338 + P310

[ Target Organs ]:
Thyroid.

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R40

[ Safety Phrases ]:
S45-S36/37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
YS9800000

[ HS Code ]:
29309070

Synthetic Route

Precursor & DownStream

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%


Related Compounds