Betazole

Names

[ CAS No. ]:
105-20-4

[ Name ]:
Betazole

[Synonym ]:
2-(1(2)H-Pyrazol-3-yl)-aethylamin
3-(2-aminoethyl)pyrazole
Ametazole
3-(2-Aminoethyl)-1H-pyrazole
3-(2-Aminoethyl)pyrazol
2-(1H-pyrazol-5-yl)ethanamine(SALTDATA: FREE)
2-(1(2)H-pyrazol-3-yl)-ethylamine
EINECS 203-278-3

Biological Activity

[Description]:

Betazole (Ametazole), a pyrazole analogue of histamine, is an orally active H2 receptor agonist. Betazole induces gastric acid secretion, and causes an immediate and significant increase in common bile duct pressure. Betazole has been used as a diagnostic agent known as histalog, for investigating gastric acid secretory capacity[1][2][3].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Metabolic Disease

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[Target]

H2 Receptor

[In Vitro]

Betazole (Ametazole) is a weak histamine agonist with relative selectivity towards H2 receptors and only minimal H1 activity. Betazole induces gastric inhibitory polypeptide (GIP) secretion[1].

[References]

[1]. Maples MD, Effects of betazole hydrochloride and cimetidine on common bile pressure and duodenal myoelectric activity in the dog. Am Surg. 1981;47(12):519-521.

[2]. Spitz IM, Betazole-induced GIP secretion is not mediated by gastric HCl. Metabolism. 1982;31(4):380-382.

[3]. CLAYMAN CB,. A simple oral gastric secretory stimulant (betazole hydrochloride). JAMA. 1961;175:908-909.

Chemical & Physical Properties

[ Density]:
1.14g/cm3

[ Boiling Point ]:
284.1ºC at 760mmHg

[ Melting Point ]:
25°C

[ Molecular Formula ]:
C₅H₉N₃

[ Molecular Weight ]:
111.14500

[ Flash Point ]:
150.3ºC

[ Exact Mass ]:
111.08000

[ PSA ]:
54.70000

[ LogP ]:
0.61120

[ Vapour Pressure ]:
0.00303mmHg at 25°C

[ Index of Refraction ]:
1.567

Safety Information

[ HS Code ]:
2933199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933199090

[ Summary ]:
2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%