p-Benzoquineone dioxime
Names
[ CAS No. ]:
105-11-3
[ Name ]:
p-Benzoquineone dioxime
[Synonym ]:
(1Z,4Z)-N,N'-Dihydroxy-2,5-cyclohexadiene-1,4-diimine
2,5-Cyclohexadiene-1,4-dione, dioxime, (1Z,4Z)-
p-Quinone dioxime (p-Benzoquinone dioxime)
p-Quinone Dioxime
(1Z,4Z)-N,N'-Dihydroxycyclohexa-2,5-diene-1,4-diimine
2,5-Cyclohexadiene-1,4-dione, dioxime, (1E,4E)-
1,4-Benzoquinone dioxime
N-(4-nitrosophenyl)hydroxylamine
p-Benzoquineone dioxime
(1E,4E)-N,N'-Dihydroxy-2,5-cyclohexadiene-1,4-diimine
(1E,4E)-N,N'-Dihydroxycyclohexa-2,5-diene-1,4-diimine
p-Benzoquinonedioxime
EINECS 203-271-5
MFCD00063636
p-Benzoquinone dioxime
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
303.0±42.0 °C at 760 mmHg
[ Melting Point ]:
243 °C (dec.)(lit.)
[ Molecular Formula ]:
C6H6N2O2
[ Molecular Weight ]:
138.124
[ Flash Point ]:
182.5±17.1 °C
[ Exact Mass ]:
138.042923
[ PSA ]:
65.18000
[ LogP ]:
1.89
[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C
[ Index of Refraction ]:
1.594
[ Storage condition ]:
-20°C
[ Stability ]:
Stable. Incompatible with strong acids, strong oxidizing agents.
[ Water Solubility ]:
<0.01 g/100 mL at 22.5 ºC
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DK4900000
- CHEMICAL NAME :
- p-Benzoquinone, dioxime
- CAS REGISTRY NUMBER :
- 105-11-3
- BEILSTEIN REFERENCE NO. :
- 2043234
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 19
- MOLECULAR FORMULA :
- C6-H6-N2-O2
- MOLECULAR WEIGHT :
- 138.14
- WISWESSER LINE NOTATION :
- L6Y DYJ AUNQ DUNQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 464 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1420 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1456 mg/kg/35W-I
- TOXIC EFFECTS :
- Behavioral - alteration of classical conditioning Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 14 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 131 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - mouse Lymphocyte
- DOSE/DURATION :
- 25 mg/L
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 12,85,1988 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 29,185,1982 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 29,185,1982 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81967 No. of Facilities: 45 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 732 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81967 No. of Facilities: 18 (estimated) No. of Industries: 1 No. of Occupations: 7 No. of Employees: 1811 (estimated) No. of Female Employees: 17 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R22;R40
[ Safety Phrases ]:
S45-S36/37
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
DK4900000
[ HS Code ]:
2942000000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2928000090
[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%
Articles
Environ. Mol. Mutagen. 19(1) , 71-6, (1992)
P-Benzoquinone dioxime (BQD) appears to be a sex-specific rat carcinogen inducing tumours of the urinary bladder in female rats. The present paper shows that BQD is a direct-acting mutagen in Salmonel...
para-Benzoquinone dioxime.IARC Monogr. Eval. Carcinog. Risk Chem. Hum. 29 , 185-91, (1982)
1,4-Benzoquinone dioxime.
IARC Monogr. Eval. Carcinog. Risks Hum. 71 Pt 3 , 1251-4, (1999)