[Pro9]-Substance P

Names

[ Name ]:
[Pro9]-Substance P

[Synonym ]:
H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Pro-Leu-Met-NH2
9-L-PROLINE-SUBSTANCE P
substance P,Pro(9)
RPKPQQFFPLM-NH2
[TYR9]-SUBSTANCE P
[Pro9]SP
[PRO9] SUBSTANCE P
L-Arg-L-Pro-L-Lys-L-Pro-L-Gln-L-Gln-L-Phe-L-Phe-L-Pro-L-Leu-L-Met-NH2
pro(9)-substance
[Pro9]-Substance P

Biological Activity

[Description]:

[Pro9]-Substance P is a potent, reversible and selective agonist of NK-1 tachykinin receptors with an EC50 of 0.93 nM[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[Target]

NK1:0.93 nM (EC50)

[In Vitro]

[3H][Pro9]-Substance P can be used as a radio ligand for NK- 1 binding sites[1]. [Pro9]-Substance P stimulates inositol phosphate formation with an efficacy only slightly lower than that of SP (EC50 values of 0.93 ± 0.07 and 0.45 ± 0.06 nM, respectively) on primary cultures of newborn mouse cortical glial cells[1].

Chemical & Physical Properties

[ Density]:
1.43g/cm3

[ Molecular Formula ]:
C₆₆H₁₀₂N₁₈O₁₃S

[ Molecular Weight ]:
1387.69000

[ Exact Mass ]:
1386.76000

[ PSA ]:
533.14000

[ LogP ]:
4.61590

[ Index of Refraction ]:
1.669

Safety Information

[ WGK Germany ]:
3

Related Compounds

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