RO 5203648

Names

[ Name ]:
RO 5203648

[Synonym ]:
(4S)-4-(3,4-Dichlorophenyl)-4,5-dihydro-1,3-oxazol-2-amine
2-Oxazolamine, 4-(3,4-dichlorophenyl)-4,5-dihydro-, (4S)-

Biological Activity

[Description]:

RO5203648 is a potent and highly selective partial agonist of TAAR1 (Trace amine-associated receptor 1) with high affinity. RO5203648 demonstrates a novel paradigm for neuropsychiatric therapeutics[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Revel FG, et al. Trace amine-associated receptor 1 partial agonism reveals novel paradigm for neuropsychiatric therapeutics. Biol Psychiatry. 2012 Dec 1;72(11):934-42.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
351.5±52.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₈Cl₂N₂O

[ Molecular Weight ]:
231.08

[ Flash Point ]:
166.4±30.7 °C

[ Exact Mass ]:
230.001373

[ LogP ]:
2.19

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.663

[ Storage condition ]:
2-8°C

Related Compounds

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