Aminooxy-PEG2-azide

Names

[ Name ]:
Aminooxy-PEG2-azide

Biological Activity

[Description]:

Aminooxy-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Aminooxy-PEG2-azide is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Non-cleavable

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

[References]

[1]. H. Tetsuo Uyeda, et al. Synthesis of surface ligands to prepare hydrophilic and biologically compatible quantum dots. doi: 10.1117/12.590494.

[2]. Song, Ho Young, et al. Pyrrolobenzodiazepine dimer precursor and ligand-linker conjugate compound thereof.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆H₁₄N₄O₃

[ Molecular Weight ]:
190.20

[ Storage condition ]:
2-8°C

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.