Pirenoxine

Names

[ Name ]:
Pirenoxine

[Synonym ]:
1-hydroxy-5-oxo-5H-pyrido[3,2-a]-phenoxazine-3-carboxylic acid
Pirenoxina [Spanish]
1,5-dioxo-1,5-dihydro-4H-pyrido[3,2-a]phenoxazine-3-carboxylic acid
pirenoxine
Pirenoxinum
EINECS 213-872-4
1-Hydroxy-pyrido-5-phenoxazon-3-carbonsaeure
Pirenoxinum [Latin]
Catalin
Catalin-K (TN)
MFCD00867148
Pirenoxina
pirfenoxone

Biological Activity

[Description]:

Pirenoxine (Catalin K) is a potent antioxidant. Pirenoxine shows anti-presbyopic activity. Pirenoxine has the potential for the research of cataracts[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[In Vivo]

Pirenoxine (0.005% pirenoxine；滴眼液) 抑制晶状体硬化并防止老花眼的发展[2]。 Animal Model: Six-week-old male Sprague-Dawley rats[2] Dosage: 0.005% pirenoxine Administration: Eye drop Result: Significantly suppressed lens hardening.

[References]

[1]. Upaphong P, et al. The Possible Positive Mechanisms of Pirenoxine in Cataract Formation. Int J Mol Sci. 2022 Aug 21;23(16):9431.

[2]. Tsuneyoshi Y, et al. Suppression of presbyopia progression with pirenoxine eye drops: experiments on rats and non-blinded, randomized clinical trial of efficacy. Sci Rep. 2017 Jul 28;7(1):6819.

Chemical & Physical Properties

[ Density]:
1.7g/cm3

[ Boiling Point ]:
515.8ºC at 760mmHg

[ Melting Point ]:
247-248ºC

[ Molecular Formula ]:
C₁₆H₈N₂O₅

[ Molecular Weight ]:
308.25

[ Flash Point ]:
265.7ºC

[ Exact Mass ]:
308.04300

[ PSA ]:
113.52000

[ LogP ]:
2.24480

[ Vapour Pressure ]:
1.83E-11mmHg at 25°C

[ Index of Refraction ]:
1.793

Related Compounds

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