H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-OH

Names

[ Name ]:
H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-OH

[Synonym ]:
DRVYIHPFHLVIHN
Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn
ANGIOTENSINOGEN,Fragment 1-14
Renin Substrate, human
H-DRVYIHPFHLVIHN-OH
ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-VAL-ILE-HIS-ASN
Angiotensinogen (1-14), human

Biological Activity

[Description]:

Angiotensinogen (1-14), human is a fragment of the renin substrate angiotensinogen, a precursor for all angiotensin peptides.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Peptides

Research Areas >> Cardiovascular Disease

[In Vitro]

Angiotensinogen (AGT) is the only precursor of all angiotensin peptides. Human AGT has 485 amino acids, including a 33 amino-acid signal peptide. The 10 N-terminal amino acids are cleaved by renin to provide angiotensin I (AngI), which is the source for an array of active angiotensin peptides[1].

[References]

[1]. Lu H, et al. Structure and functions of angiotensinogen. Hypertens Res. 2016 Jul;39(7):492-500.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₈₃H₁₂₂N₂₄O₁₉

[ Molecular Weight ]:
1760.01000

[ Exact Mass ]:
1758.93000

[ PSA ]:
681.39000

[ LogP ]:
4.57920

MSDS

Click to get detail MSDS

Safety Information

[ WGK Germany ]:
3