N,N-Diethylpropan-1,3-diamin

Names

[ CAS No. ]:
104-78-9

[ Name ]:
N,N-Diethylpropan-1,3-diamin

[Synonym ]:
EINECS 203-236-4
DIETHYLAMINO PROPYLAMINE
N,N-Diethylpropanediamine
3-dietgylpropanediamine
ATOFINA DEAPA
1,3-Propanediamine, N,N-diethyl-
N,N-Diethylpropan-1,3-diamin
N,N-diethylpropane-1,3-diamine
RARECHEM AL BW 0333
FENTAMINE DEAPA
N1,N1-diethylpropane-1,3-diamine
DEAPA
3-Aminopropyldiethylamine
N,N-diethyl-3-aminopropylamine
MFCD00008218
3-(Diethylamino)propylamine
N,N-Diethyl-1,3-diaminopropane
3-Diethylaminopropyl
N,N'-Diethyl-1,3-diaminopropane
N,N-Diethyl-1,3-propanediamine
γ-(Diethylamino)propylamine

Chemical & Physical Properties

[ Density]:
0.8±0.1 g/cm3

[ Boiling Point ]:
170.7±8.0 °C at 760 mmHg

[ Melting Point ]:
-60 °C

[ Molecular Formula ]:
C₇H₁₈N₂

[ Molecular Weight ]:
130.231

[ Flash Point ]:
58.9±0.0 °C

[ Exact Mass ]:
130.147003

[ PSA ]:
29.26000

[ LogP ]:
0.77

[ Vapour density ]:
4.4 (vs air)

[ Vapour Pressure ]:
1.5±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.451

[ Water Solubility ]:
MISCIBLE

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TX7350000

CHEMICAL NAME :: 1,3-Propanediamine, N,N-diethyl-

CAS REGISTRY NUMBER :: 104-78-9

BEILSTEIN REFERENCE NO. :: 0741879

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C7-H18-N2

MOLECULAR WEIGHT :: 130.27

WISWESSER LINE NOTATION :: Z3N2&2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1410 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 2/27/1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 750 uL/kg

TOXIC EFFECTS :: Skin and Appendages - primary irritation (after topical exposure)

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84789 No. of Facilities: 201 (estimated) No. of Industries: 12 No. of Occupations: 15 No. of Employees: 2240 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84789 No. of Facilities: 17 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 460 (estimated) No. of Female Employees: 63 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H226-H302 + H312-H314-H317

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R10;R21/22;R34;R43

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 2684 3/PG 3

[ WGK Germany ]:
1

[ RTECS ]:
TX7350000

[ Packaging Group ]:
III

[ Hazard Class ]:
3

[ HS Code ]:
29212900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2921290000

[ Summary ]:
2921290000 other acyclic polyamines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Amine-modified poly(vinyl alcohol)s as non-viral vectors for siRNA delivery: effects of the degree of amine substitution on physicochemical properties and knockdown efficiency.

Pharm. Res. 27(12) , 2670-82, (2010)

The objective of this study was to investigate how the degree of amine substitution of amine-modified poly(vinyl alcohol) (PVA) affects complexation of siRNA, protection of siRNA against degrading enz...

Low toxicity and long circulation time of polyampholyte-coated magnetic nanoparticles for blood pool contrast agents. Wang Qi, et al.

Sci. Rep. 5 , 7774, (2015)

Hyaluronated nanoparticles with pH-and enzyme-responsive drug release properties. Kim SW, et al.

Colloids Surf. B Biointerfaces 116 , 359-364, (2014)