macrocalin A

Names

[ Name ]:
macrocalin A

[Synonym ]:
(1S,4S,8R,9R,12S,13S,16R)-9-Hydroxy-7,7-dimethyl-17-methylene-3,10-dioxapentacyclo[14.2.1.0.0.0]nonadecane-2,18-dione
5H-5a,8-Methano-11H-cyclohepta[c]furo[3,4-e][1]benzopyran-5,6(7H)-dione, decahydro-13-hydroxy-1,1-dimethyl-7-methylene-, (3aS,5aS,8R,10aS,10bS,13R,13aR)-

Biological Activity

[Description]:

(-)-Isodocarpin (Isodocarpin), a diterpenoid, is a potent melanogenesis inhibitor with an IC50 of 0.19 μM in B16 4A5 cells. (-)-Isodocarpin inhibits the expression of tyrosinase, tyrosine-related protein (TRP)-1, and TRP-2 mRNA[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

Signaling Pathways >> GPCR/G Protein >> Melanocortin Receptor

[References]

[1]. Yoshiaki Manse, et al. Melanogenesis Inhibitory Activity of Diterpenoid and Triterpenoid Constituents from the Aerial Part of Isodon trichocarpus. Natural Product Communications. August 1, 2017.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
568.7±50.0 °C at 760 mmHg

[ Melting Point ]:
270-273℃

[ Molecular Formula ]:
C₂₀H₂₆O₅

[ Molecular Weight ]:
346.417

[ Flash Point ]:
205.0±23.6 °C

[ Exact Mass ]:
346.178009

[ PSA ]:
72.83000

[ LogP ]:
0.94

[ Vapour Pressure ]:
0.0±3.5 mmHg at 25°C

[ Index of Refraction ]:
1.584

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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