2-Pyrazinamine,N-nitroso-
Names
[ CAS No. ]:
103829-56-7
[ Name ]:
2-Pyrazinamine,N-nitroso-
[Synonym ]:
pyrazin-2-yl-diazenol
pyrazine-2-diazohydroxide
Pyrazinyl-(2)-diazohydroxid
Chemical & Physical Properties
[ Density]:
1.47g/cm3
[ Boiling Point ]:
227.1ºC at 760mmHg
[ Molecular Formula ]:
C4H4N4NaO+
[ Molecular Weight ]:
147.09100
[ Flash Point ]:
91.1ºC
[ Exact Mass ]:
147.02800
[ PSA ]:
70.73000
[ LogP ]:
0.94950
[ Vapour Pressure ]:
0.0791mmHg at 25°C
[ Index of Refraction ]:
1.67
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UQ2010000
- CHEMICAL NAME :
- Pyrazinamine, N-nitroso-
- CAS REGISTRY NUMBER :
- 103829-56-7
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C4-H4-N4-O
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 176 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Skin and Appendages - hair
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB88-239900
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Blood - leukopenia Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 29,511,1988 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 150 mg/kg/5D-I
- TOXIC EFFECTS :
- Blood - changes in bone marrow (not otherwise specified) Related to Chronic Data - death Related to Chronic Data - changes in testicular weight
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB88-239900