(6R)-FR054

Names

[ Name ]:
(6R)-FR054

[Synonym ]:
4',5'-dihydro-2'-methoxyoxazolo[5',4':1,2]-3,4,6-tri-O-acetyl-1,2-dideoxy-α-D-glucopyranoside
2-methyl-(3,4,6-tri-O-acetyl-1,2-dideoxy-α-D-glucopyrano)-<2,1-d>-2-oxazoline
4',5'-dihydro-2'-methyloxazolo[5',4':1,2]-3,4,6-tri-O-acetyl-1,2-dideoxy-α-D-glucopyranose
2-methyl-(3,4,6-tri-O-acetyl-1,2-dideoxy-α-D-glucopyranoso)-[2,1-d]-2-oxazoline
2-methyl-(3,4,6-tri-O-acetyl-1,2-dideoxy-α-D-glucopyrano)-[2',1':4,5]-2-oxazoline
2-methyl-(3,4,6-tri-O-acetyl-1,2-dideoxy-α-D-glucopyranosido)-[2,1-d]-2-oxazoline

Biological Activity

[Description]:

(6R)-FR054 is an active isomer of FR054. FR054 is an inhibitor of the HBP enzyme PGM3, with a remarkable anti-breast cancer effect. FR054induces endoplasmic reticulum (ER) stress and a ROS-dependent apoptosis[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[References]

[1]. Francesca Ricciardiello, et al. Inhibition of the Hexosamine Biosynthetic Pathway by Targeting PGM3 Causes Breast Cancer Growth Arrest and Apoptosis. Cell Death Dis. 2018 Mar 7;9(3):377.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₉NO₈

[ Molecular Weight ]:
329.30300

[ Exact Mass ]:
329.11100

[ PSA ]:
109.72000

[ Storage condition ]:
2-8°C

Precursor & DownStream

Precursor

DownStream

Related Compounds

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