Saridegib

Names

[ Name ]:
Saridegib

[Synonym ]:
unii-jt96fpu35x
ipi 926
ip9 free base
saridegib
fin-5

Biological Activity

[Description]:

Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> Smo

Research Areas >> Cancer

[Target]

Smo[1].

[In Vivo]

Evidence from a genetically engineered mouse model of pancreatic cancer demonstrates that Saridegib (IPI-926) can deplete tumor-associated stromal tissue and increase intratumoral mean vessel density. These changes result in enhanced delivery of concurrently administered systemic agents such as gemcitabine, leading to a decreased tumor burden and prolonged survival in this mouse model[1].

[References]

[1]. Ko AH, et al. A Phase I Study of FOLFIRINOX Plus IPI-926, a Hedgehog Pathway Inhibitor, for Advanced Pancreatic Adenocarcinoma. Pancreas. 2016 Mar;45(3):370-5.

[Related Small Molecules]

SAG.HCI | Purmorphamine | LDE225 (NVP-LDE225,Erismodegib) | PF-04449913 | Jervine | LY2940680 | BMS-833923 | LEQ506 | MK-4101 | MRT-83 | PF-5274857

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₄₈N₂O₃S

[ Molecular Weight ]:
504.76800

[ Exact Mass ]:
504.33900

[ PSA ]:
75.81000

[ LogP ]:
6.82930

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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