SPV 106

Names

[ Name ]:
SPV 106

[Synonym ]:
SPV 106

Biological Activity

[Description]:

SPV106 is histone acetylase (HAT) and GCN5-related N-acetyltransferases (GNAT) activator. SPV106 can be used for the research of type 2 diabetes (T2D)[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

Signaling Pathways >> Epigenetics >> Histone Acetyltransferase

[In Vitro]

SPV106 恢复正常水平的 H3K9Ac 和 H3K14Ac，降低 DNA CpG 高甲基化，恢复 D-CMSC 增殖和分化[1]。 SPV106 (5 µmol/L) 在 D-CMSC[1] 中减少细胞衰老并诱导 cKit 表达[1]。 Western Blot Analysis[1] Cell Line: Human cardiac-specific mesenchymal cell (CMSC) Concentration: 25 μmol/L Incubation Time: 6-8 days Result: Achieved partial but significant rescue of HAT activity. RT-PCR[1] Cell Line: Human cardiac-specific mesenchymal cell (CMSC) Concentration: 25 μmol/L Incubation Time: 7 days Result: Not associated to a rescue in gene transcription.

[References]

[1]. Matteo Vecellio, et al. The histone acetylase activator pentadecylidenemalonate 1b rescues proliferation and differentiation in the human cardiac mesenchymal cells of type 2 diabetic patients. Diabetes. 2014 Jun;63(6):2132-47.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₄₀O₄

[ Molecular Weight ]:
368.55100

[ Exact Mass ]:
368.29300

[ PSA ]:
52.60000

[ LogP ]:
6.13020

MSDS

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Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H317

[ Precautionary Statements ]:
P280

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds

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