AZD 9164

Names

[ Name ]:
AZD 9164

[Synonym ]:
1-Azoniabicyclo[2.2.2]octane, 1-[2-(4-fluorophenyl)ethyl]-3-[(2S)-1-oxo-2-phenyl-2-(1-piperidinyl)propoxy]-, (3R)-
(3R)-1-[2-(4-Fluorophenyl)ethyl]-3-{[(2S)-2-phenyl-2-(1-piperidinyl)propanoyl]oxy}-1-azoniabicyclo[2.2.2]octane

Biological Activity

[Description]:

A novel highly potent, selective, long acting muscarinic receptor M3 antagonist with pIC50 of 9.8, 10-fold selectivity over M2 (pIC50=9.0); demonstrates potential as a treatment for COPD. COPD Phase 2 Discontinued

[References]

References 1. Mete A, et al. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6248-53. 2. Bjermer L, et al. Respir Med. 2013 Jan;107(1):84-90. 3. Mastrodicasa MA, et al. Expert Opin Investig Drugs. 2017 Feb;26(2):161-174. View Related Products by Target mAChR COPD

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₃₈FN₂O₂+

[ Molecular Weight ]:
465.622

[ Exact Mass ]:
465.291168

[ LogP ]:
2.49

Related Compounds

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