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(-)-(S)-Cibenzoline

Names

[ CAS No. ]:
103419-18-7

[ Name ]:
(-)-(S)-Cibenzoline

[Synonym ]:
2-[(1S)-2,2-Diphenylcyclopropyl]-4,5-dihydro-1H-imidazole
1H-Imidazole, 2-[(1S)-2,2-diphenylcyclopropyl]-4,5-dihydro-
EINECS 258-453-7

Biological Activity

[Description]:

(-)-(S)-Cibenzoline (Escibenzoline), a S(+)-enantiomer of Cibenzoline, is an antiarrhythmic agent[1].

[Related Catalog]:

Research Areas >> Metabolic Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[References]

[1]. T Niwa, et al. Stereoselective metabolism of cibenzoline, an antiarrhythmic drug, by human and rat liver microsomes: possible involvement of CYP2D and CYP3A. Drug Metab Dispos. 2000 Sep;28(9):1128-34.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
449.2±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H18N2

[ Molecular Weight ]:
262.35

[ Flash Point ]:
225.5±28.7 °C

[ Exact Mass ]:
262.147003

[ LogP ]:
3.81

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.656

Related Compounds