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AS 2034178

Names

[ CAS No. ]:
1030846-42-4

[ Name ]:
AS 2034178

[Synonym ]:
Benzenepropanoic acid, 2-fluoro-4-[[[1,2,3,4-tetrahydro-1-(2-phenoxyethyl)-5-quinolinyl]methyl]amino]-
3-[2-Fluoro-4-({[1-(2-phenoxyethyl)-1,2,3,4-tetrahydro-5-quinolinyl]methyl}amino)phenyl]propanoic acid
AS2034178

Biological Activity

[Description]:

AS2034178 free base, a specific and orally active GPR40 agonist, exhibits glucose-dependent insulin secretion enhancement. AS2034178 free base has potential for type 2 diabetes mellitus research[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> GPR40
Research Areas >> Metabolic Disease

[References]

[1]. Tanaka H, et al. Chronic treatment with novel GPR40 agonists improve whole-body glucose metabolism based on the glucose-dependent insulin secretion. J Pharmacol Exp Ther. 2013;346(3):443-452.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
657.9±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C27H29FN2O3

[ Molecular Weight ]:
448.52900

[ Flash Point ]:
351.7±31.5 °C

[ Exact Mass ]:
448.21600

[ PSA ]:
61.80000

[ LogP ]:
5.44

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.622

Related Compounds