1-Carbamoyl-2-phenylhydrazin

Names

[ CAS No. ]:
103-03-7

[ Name ]:
1-Carbamoyl-2-phenylhydrazin

[Synonym ]:
EINECS 203-072-3
MFCD00007942
anilinourea

Biological Activity

[Description]:

1-Phenylsemicarbazide is an antifungal agent. 1-Phenylsemicarbazide has the potential for preventing mold growth on industrial products[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

[References]

[1]. Iwamoto, Hiromichi, et al. Prevention of mold growth on industrial products. XI. Antifungal activities of various fungicides. 5. Organic nitrogen-sulfur compounds.

Chemical & Physical Properties

[ Density]:
1.275g/cm3

[ Melting Point ]:
171-174 °C(lit.)

[ Molecular Formula ]:
C₇H₉N₃O

[ Molecular Weight ]:
151.16600

[ Exact Mass ]:
151.07500

[ PSA ]:
67.15000

[ LogP ]:
1.84600

[ Index of Refraction ]:
1.601

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FD0575000

CHEMICAL NAME :: Carbamic acid, 2-phenylhydrazide

CAS REGISTRY NUMBER :: 103-03-7

BEILSTEIN REFERENCE NO. :: 0743311

LAST UPDATED :: 199707

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C7-H9-N3-O

MOLECULAR WEIGHT :: 151.19

WISWESSER LINE NOTATION :: ZVMMR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 198 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 394 mg/kg/62W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

MUTATION DATA

TYPE OF TEST :: DNA repair

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 250 ug/well

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 133,161,1984 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 12,177,1976 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 12,177,1976 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S45-S36/37/39-S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
FD0575000

[ HS Code ]:
2928000090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2928000090

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Articles

New one-pot, efficient, and regioselective method for the synthesis of 3-Trifluoromethyl-1< i> H</i>-1-phenylpyrazoles and alkyl 3-carboxylate analogs. Bonacorso HG, et al.

Tetrahedron Lett. 53(41) , 5488-5491, (2012)

Related Compounds

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